Effects of double intravenous furosemide administration at different doses on clinical variables, electrocardiographic indices and serum electrolytes in miniature donkeys

The intravenous (IV) usage of diuretics such as furosemide may cause changes in clinical variables, electrocardiographic (ECG) indices and some serum electrolytes concentrations in miniature donkeys. The purpose of this study was to evaluate the effects of double intravenous (IV) administration of furosemide at different doses on the clinical variables, ECG indices and serum electrolytes levels in miniature donkeys. A total of ۲۱ clinically and para-clinically healthy miniature donkeys with a mean age of ۶.۰۰ ± ۱.۰۰ years and weight of ۹۵.۰۰ ± ۵.۰۰ kg were used. The animals were randomly divided into three groups of control (normal saline) and low- (۱.۰۰ mg kg-۱) and high-dose (۲.۰۰ mg kg-۱) of furosemide. Two IV injections with ۱۲-hr interval were administered in each animal. The clinical and ECG parameters were measured at ۰ (baseline), ۲ (T۲), ۲۴ (T۲۴) and ۴۸ (T۴۸) hr after drug administration. Serum concentrations of electrolytes were measured at T۰, T۲۴ and T۴۸. The results of this study showed no changes in clinical variables (heart rate, rectal temperature and respiratory rate) and ECG indices (amplitude and duration of P, QRS and T waves and duration of PR, QT and RR intervals) as well as no significant changes in serum electrolytes (sodium, potassium, chloride, phosphorus, calcium and magnesium) levels. Although no significant effect on clinical variables, electrolytes levels and ECG indices after double IV administration of furosemide (۱.۰۰ and ۲.۰۰ mg kg-۱) in miniature donkeys was observed, absence of these effects does not mean that furosemide had no pharmacological effect.

کلیدواژه ها:

Electrocardiographic indices ، Furosemide ، Intravenous administration ، Macro-minerals ، Miniature donkey