Evidence of morphine like substance and μ-opioid receptor expression in Toxacara canis (Nematoda: Ascaridae)
محل انتشار: گفتمان پژوهش دامپزشکی، دوره: 7، شماره: 4
سال انتشار: 1395
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 39
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شناسه ملی سند علمی:
JR_VRFAN-7-4_010
تاریخ نمایه سازی: 25 آبان 1402
چکیده مقاله:
Toxocara canis (Nematoda: Ascaridae) is an intestinal nematode parasite of dogs, which can also cause disease in humans. Transmission to humans usually occurs because of direct contact with T. canis eggs present in soil contaminated with the feces of infected dogs. This nematode has extraordinary abilities to survive for many years in different tissues of vertebrates, and develop to maturity in the intestinal tract of its definitive host. Survival of parasitic nematodes within a host requires immune evasion using complicated pathways. Morphine-like substance, as well as opioids, which are known as down regulating agents, can modulate both innate and acquired immune responses, and let the parasite survives in their hosts. In the present study, we aimed to find evidences of morphine-like substance and µ-opiate receptor expression in T. canis, using high performance liquid chromatography (HPLC) and reverse transcription polymerase chain reaction (RT-PCR). The results indicated that T. canis produced morphine-like substances at the level of ۲.۳۱± ۰.۲۶ ng g-۱ wet weight, and expressed µ-opiate receptor as in expected size of ۴۴۱ bp. According to our findings, it was concluded that T. canis, benefits using morphine-like substance to modulate host immunity.
کلیدواژه ها:
نویسندگان
Mostafa Golabi
Department of Pathobiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
Soraya Naem
Department of Pathobiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
Mehdi Imani
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
Nowruz Dalirezh
Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
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