miRNAs and rheumatoid arthritis: new update in expression pattern and pathogenicity
محل انتشار: فصلنامه تحقیقات روماتولوژی، دوره: 6، شماره: 3
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 128
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شناسه ملی سند علمی:
JR_RHRE-6-3_001
تاریخ نمایه سازی: 24 آبان 1402
چکیده مقاله:
Rheumatoid arthritis (RA) is a polygenic autoimmune disease characterized by systemic inflammation and disability of joints. Early diagnosis and treatment could prevent diseases in RA patients from becoming severe. miRNAs are small, non-coding RNA that regulate the post-transcriptional level of gene expression. miRNAs play important roles in gene expression and pathogenicity of autoimmune diseasesas well as RA. Properly using miRNAs regulation potential and detecting different expression patterns andtheir functions could facilitate and manage effective therapeuticinterventions in RA patients. Herein, we discuss miRNAs as a therapeutic agent in RA patients.
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نویسندگان
Hamidreza Ebrahimiyan
۱. Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran ۲. Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran
Arman Ahmadzadeh
Department of Rheumatology, Loghman Hakim Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran