Effect of Vitamin C Therapy on Serum Parameters in Patients with Type ۲ Diabetes Mellitus: Clinical Trial

Objective: Diabetes mellitus (DM) is a leading cause of morbidity and death worldwide. DM will affect ۵۷۰.۹ million people worldwide by ۲۰۲۵. The usefulness of vitamin C in improving diabetes control has been a point of contention. Materials and Methods: This clinical-trial double-blind study with control groups was conducted on ۱۶۴ patients with type ۲ diabetes mellitus (T۲DM). The intervention group received ۱۰۰۰ mg of oral vitamin C daily, and a placebo was administered to the controls. To analyze the obtained data, one-way ANOVA was used in SPSS software (version ۲۰). A P< ۰.۰۵ was considered statistically significant. Results: Fasting blood sugar (FBS), hemoglobin A۱c (HbA۱C), triglyceride (TG), and high-density lipoprotein (HDL) were improved significantly in the intervention group (P< ۰.۰۵), while the low-density lipoprotein (LDL) and cholesterol were unaffected (P> ۰.۰۵). HbA۱C and LDL levels in the control group increased significantly (P< ۰.۰۵). Meanwhile, this group's HDL levels decreased considerably. Conclusion: Our findings support the consumption of vitamin C to complement the primary treatment for DM. According to our results, vitamin C provides a clear benefit over a placebo in the treatment of diabetic patients' serum parameters.

کلیدواژه ها:

Clinical trial ، Diabetes mellitus ، Blood glucose ، HbA۱C ، HDL ، LDL ، Ascorbic acid