The Effects of High Intensity Interval Training on HNF-۴ α Gene Expression in Liver Tissue of Type ۲ Diabetic Male Wistar Rats

سال انتشار: 1397
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 123

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شناسه ملی سند علمی:

JR_IJDO-10-4_007

تاریخ نمایه سازی: 16 آبان 1402

چکیده مقاله:

Objective: This study examined the effect of high intensity interval training (HIIT) on HNF-۴α gene expression, glucose and insulin in liver tissue of type ۲ diabetic male Wistar rats. Materials and Methods: In this study, ۲۰ male Wistar rats weighing ۲۲۰ (±۲۰) grams were selected. After type ۲ diabetes (T۲D) induction, the samples were divided into two groups of HIIT and control. The training program was ۱۲ weeks and ۵ times a week. Fasting glucose, serum insulin and HNF-۴α gene expression in the liver tissue were measured in both groups after the last exercise session by using independent T-test. Results: The results showed that HIIT decreased significantly the fasting glucose (P-value: ۰.۰۰۱) and increased serum insulin (P-value: ۰.۰۰۱). Also, the expression of HNF-۴α after HIIT significantly decreased in comparison to the control group (P-value: ۰.۰۰۳). Conclusion: Based on the findings, HIIT resulted in a significant decrease in fasting glucose and a significant increase in insulin that is likely to reduce the liver HNF-۴α gene expression of T۲D male Wistar rats by increasing serum insulin.

کلیدواژه ها:

High intensity intermittent exercise ، HNF-۴α gene expression ، Type ۲ diabetic ، Wistar rat

نویسندگان

Elham Yadegari

PhD Student, Department of Exercise Physiology, South Tehran Branch, Islamic Azad University, Tehran, Iran.

Abdol Ali Banaeifar

PhD, Department of Exercise Physiology, South Tehran Branch, Islamic Azad University, Tehran, Iran

Mohamad Ali Azarbayjani

PhD, Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran

Sajad Arshadi

PhD, Department of Exercise Physiology, South Tehran Branch, Islamic Azad University, Tehran, Iran

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