Propofol Unveiled: A Novel Approach to Inducing Diabetes in Wistar Rats

Alloxan and streptozotocin are commonly used to induce diabetes in animal models. They destroy pancreaticbeta cells through different mechanisms. However, their limitations include laboratory toxicity andlow efficacy at high doses. Combining a new generation of diabetes-inducing agents with propofol offersimproved efficiency, effectiveness, and cost-effectiveness. Both substances cause diabetes by generatingreactive oxygen species, but the source of these radicals differs. Alloxan and its reduced product, dialuricacid, create superoxide radicals, leading to pancreatic tissue damage. Streptozotocin enters beta cellsthrough GLUT۲ and induces DNA alkylation, depleting NAD+ and ATP levels, and increasing xanthineoxidase enzyme activity. Propofol intensifies the defects caused by the other substances, triggering nervepathways that inhibit repair and producing free radicals, which damage the pancreas. In the study, alloxan,streptozotocin, and propofol induced diabetes in ۴۰ Wistar laboratory rats, resulting in hyperglycemia andreduced insulin secretion.

کلیدواژه ها:

Propofol ، Alloxan ، Streptozotocin ، Diabetes ، Pancreatic Beta Cells.