The Impact of Resistance and Aerobic Training on the Insulin Synthesis Genes Expression in Diabetic Rats

Objective: In the last two decades, genetic studies have strongly supported the effective role of genetic factors on the synthesis of insulin from the pancreas. The purpose of this research is to determine the effect of aerobic and resistance exercises on the expression of NeruoD۱ and PDX۱ in pancreatic tissue, as well as serum insulin and glucose levels in type ۲ diabetic rats. Materials and Methods: ۲۱ male wistar rats (۲۲۰±۱۰ g) were included. Then diabetic rats were randomly assigned into ۳ groups: ۱) control (no-training), ۲) resistance training and ۳) aerobic training. Exercise training lasted ۱۰ weeks and ۵ times weekly for training groups. After intervention, NeruoD۱ and PDX۱ expression in pancreas, insulin and glucose were compared between groups. Data compared by one way ANOVA and Tukey's post hoc test between groups (P < ۰.۰۵). Results: Compared to control rats, resistance and aerobic training led to significant increase in serum insulin (P: ۰.۰۰۱, P: ۰.۰۱۳ respectively), PDX۱ expression (P: ۰.۰۰۱, P: ۰.۰۰۱ respectively) and decrease glucose (P: ۰.۰۰۱, P: ۰.۰۰۱ respectively). Significant difference was not observed between control and aerobic groups with regard to NeruoD۱ expression (P: ۰.۰۷۷). In addition, NeruoD۱ expression in resistance group was significantly higher than aerobic and control groups (P: ۰.۰۱۸, P: ۰.۰۰۱, respectively). Conclusion: Despite the improvement of insulin and glucose in response to both aerobic and resistance training, it seems that resistance training affects genes affecting insulin synthesis and transcription more than aerobic training.

کلیدواژه ها:

Insulin synthesis ، Aerobic and resistance training ، Type ۲ diabetes ، Gene’s expression