The effect of aerobic and resistance exercise with olive extract on VO۲ max, PTEN, and AKT in rats with Parkinson's disease

Introduction: Parkinson's disease is a progressive neurological disorder. The aim of this study was to investigate the effect of exercise training with the consumption of olive extract on maximal oxygen consumption (VO۲ max), phosphatase and tensin homolog on chromosome ۱۰ (PTEN), and protein kinase B (AKT) in rats with Parkinson. Material & Methods: The samples of this experimental study included male Wistar rats (n = ۳۰, ۸ weeks old, ۲۰۰ ± ۵۰ g). Animals (n = ۵ per group) were randomly divided into ۶ groups: control (C), Parkinson's (P), Parkinson's with olive extract (P+OE), Parkinson's with exercise (P+E), Parkinson's with olive extract and exercise (P+OE+E), and olive extract with exercise (OE+E) group. The training groups performed aerobic and resistance exercises for ۸ weeks (۵ sessions per week) and were also given olive extract by gavage. VO۲ max was assessed at the end of the fourth and eighth weeks of exercise. One day after the intervention, rats were sacrificed, then tissues were removed and examined for real-time PCR. One-way analysis of variance and Tukey's post hoc test were used to analyze the data. Results: The results showed that a period of exercise training combined with the consumption of olive extract significantly increased the VO۲ max in rats with Parkinson's disease (P < ۰.۰۵). The expression of the PTEN gene decreased in OE+E, P+OE+E, and P+E groups compared to P+OE and Parkinson's groups (P<۰.۰۵). AKT gene expression in all intervention groups showed a significant increase compared to the Parkinson's group (P<۰.۰۵). Conclusions: The results suggest that a period of exercise with the consumption of olive extract probably can increase the VO۲ max and AKT and decrease PTEN in rats with Parkinson's disease.

کلیدواژه ها:

Exercise ، Olive extract ، PTEN ، AKT ، Parkinson disease