Saccharomyces Cerevisiae as a Biocatalyst for Different Carbonyl Group under Green Condition

In this researchsaccharomyces cerevisiae (baker’s yeast) was used as a cheap, readily accessible, selective, efficient, and green bio-catalyst in a chemo selective reduction of carbonyl group to hydroxyl group. In this green procedure three substrates e.g. (۳-(۳-nitrophenyl)aziridin-۲-yl)-۱-phenyl-methanone, pyruvate ester, and ۲-acetyl-γ-butyrolactone were reduced to their corresponding reduced compounds in the presence of saccharomyces cerevisiae atambient temperature in aqueous media. It was worthy to note that ketone groups were chemo-selectively reduced, while ester and lactone groups remained unchanged. Moreover, in this procedure, chemo selective bio-reduction of ketone group to hydroxyl group can be performed by coenzyme NADPH in saccharomyces cerevisiae (baker’s yeast) which is recyclable in water, as a green solvent, while this recyclization cannot occur in non-aqueous systems. The structure of products was confirmed by IR and ۱H NMR spectra.

کلیدواژه ها:

Saccharomyces Cerevisiae ، Baker’s yeast ، Bio-reduction ، (۳-(۳-Nitrophenyl)aziridin-۲-yl)-۱-phenyl-methanone ، Pyruvate ester ، ۲-Acetyl-γ-butyrolactone