Synthesis and Biological Evaluation of Novel Quinoline Derivatives as Antibacterial and Antifungal Agents

Vilsmeier Several diamide derivatives containing ۲-chloroquinoline scaffolds were synthesized via Ugi reaction of ۲-chloroquinoline-۳-carboxaldehydes, amines, carboxylic acids and isocyanides. The diversity of these quinolinyl Ugi-adducts was increased by using ۲-chloroquinoline-۳-carboxylic acids as a source of acid. Among them, compounds ۲d, ۲n, ۲p, ۴a, ۴c and ۴e displayed moderate to good antibacterial and antifungal activity.

کلیدواژه ها:

Multicomponent condensation ، Quinolines ، Diamides ، antibacterial ، Antifungal