Ultrasound-assisted Method for the Synthesis of ۳-Methyl-۴-arylmethylene Isoxazole-۵(۴H)-ones Catalyzed by Imidazole in Aqueous Media
محل انتشار: دوفصلنامه تحقیقات شیمی آلی، دوره: 2، شماره: 2
سال انتشار: 1395
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 101
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شناسه ملی سند علمی:
JR_ORGC-2-2_005
تاریخ نمایه سازی: 3 مهر 1402
چکیده مقاله:
In the present study, an attempt has been made to synthesize ۳-methyl-۴-arylmethylene isoxazole-۵(۴H)-one derivatives through sonication of hydroxylamine hydrochloride, ethyl acetoacetate and benzaldehyde derivatives in the presence of imidazole as a novel and effective catalyst in aqueous media. This green reaction under ultrasound irradiation has advantageous compared to conventional procedures in view of its shorter reaction times, high isolated yields, avoidance of using organic solvents, simple experimental procedure and workup and energy conservation. A combination of the advantages of ultrasound irradiation, homogeneous catalyst and aqueous media provides an important methodology for carrying out catalytic transformations.
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نویسندگان
Javad Safari
Laboratory of Organic Chemistry Research, Department of Organic Chemistry, College of Chemistry, University of Kashan, ۸۷۳۱۷-۵۱۱۶۷ Kashan, I.R, Iran
Majid Ahmadzadeh
Laboratory of Organic Chemistry Research, Department of Organic Chemistry, College of Chemistry, University of Kashan, ۸۷۳۱۷-۵۱۱۶۷ Kashan, I.R, Iran.
Zohre Zarnegar
University of Kashan