Synthesis and Photosensitizing Properties of an Activatable Phthalocyanine-Subphthalocyanine Triad
محل انتشار: دوفصلنامه تحقیقات شیمی آلی، دوره: 3، شماره: 1
سال انتشار: 1396
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 110
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شناسه ملی سند علمی:
JR_ORGC-3-1_001
تاریخ نمایه سازی: 3 مهر 1402
چکیده مقاله:
In this article, we describe a photosensitizer (PS) whose ability to generate singlet oxygen (۱O۲) and fluorescence emission has been designed as tumor responsive. More specifically, the PS consists of a silicon phthalocyanine (SiPc) core, axially substituted with two subphthalocyanine (SubPc) units, covalently linked by a disulfide linker, which is cleavable in the presence of a strong reducing agent. Initially, the SubPc units quench the SiPc fluorescent and ۱O۲-generating properties, most probably by electronic energy transfer. Upon entering a reducing environment, e.g., like those in tumor cells, the disulfide linker would be cleaved and the quenching would be undone, resulting in a sudden generation of ۱O۲ and a strong fluorescence of both the SiPc and SubPc units. Herein, this behavior has been probed in solution by means of using DTT as the reducing agent that induces the PS activation.
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نویسندگان
Eveline Vandenwinckel
Autonoma University of Madrid
Andres de la Escosura
Autonoma University of Madrid
Tomas Torres
Autonoma University of Madrid