One Pot Synthesis of Highly Functionalized Tetrahydropyridines Using Nano-TiCl۲/cellulose as Biodegradable and Eco-Friendly Catalyst

TiCl۴/nano-cellulose as a biodegradable and eco-friendly Lewis acid catalyst was synthesized via reaction of nano-cellulose and TiCl۴. This catalyst was characterized and used for synthesis of asymmetric highly functionalized tetrahydropyridines via a five-component condensation reaction of p-substituted anilines, aldehydes and ethyl acetoacetate under solvent-free condition. Simple methodology, eco-friendly catalyst, clean procedure, easy work-up and high yields are some of the important advantages of this protocol.

کلیدواژه ها:

Nano-TiCl۲/cellulose ، Tetrahydropyridines ، Nano-cellulose ، Lewis acid catalyst ، biodegradable catalyst