Synthesis of New Benzothiazole Derivatives and Evaluation of Cytotoxicity of N-(۶-Substitued-۱,۳-benzothiazol-۲-yl)-۴-phenyl-۱,۳-thiazol-۲(۳H)-imine Compounds
محل انتشار: دوفصلنامه تحقیقات شیمی آلی، دوره: 5، شماره: 1
سال انتشار: 1398
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 77
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شناسه ملی سند علمی:
JR_ORGC-5-1_010
تاریخ نمایه سازی: 3 مهر 1402
چکیده مقاله:
Cyclization of unsymmetrical thioureas affords N-(۶-substitued-۱,۳-benzothiazol-۲-yl)-۴-phenyl-۱,۳-thiazol-۲(۳H)-imine compounds by the reaction of ۱-(۱,۳-benzothiazol-۲-yl)thiourea derivatives and ۲-bromoacetophenone in the presence of Et۳N. Also, methyl-۱,۳-benzothiazol-۲-yl carbamodithioate derivatives with methyl anthranilate were reacted and ۳-(benzo[d]thiazol-۲-yl)-۲-thioxo-۲,۳-dihydroquinazolin-۴(۱H)-one derivatives as new compounds are synthesized. In the following, synthesized compounds (۲a- ۲d) were evaluated for anti-tumor activity against MCF-۷, MAD-MD-۲۳۱, HT-۲۹, HeLa, Neuro-۲a, K-۵۶۲ and L-۹۲۹ cell lines and the results obtained from MTT-assay revealed the best cytotoxicity for ۲b compound containing a phenolic segment in their buildings. On the other hand, apoptosis assay for this compound was also carried out by flow cytometry supporting the other results.
کلیدواژه ها:
نویسندگان
Hossein Eshghi
Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, Mashhad
Fatemeh Eshkil
Department of Chemistry, Faculty of Sciences, Ferdowsi University of Mashhad, ۹۱۷۷۵-۱۴۳۶ Mashhad, Iran
Amir SHokooh Saljooghi
Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran
Mehdi Bakavoli
Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran