Aluminum Oxide Nanoparticle as a Valuable Heterogeneous Nanocatalyst in the Synthesis of ۲-Aminothiazole Scaffolds

An efficient methodology for the preparation of ۲-aminothiazoles is achieved by one-pot reaction of methylcarbonyls, thiourea and iodine in the presence of an aluminum oxide nanoparticle as an active nanocatalyst at ۸۵ °C in DMSO solvent. Al۲O۳ nanoparticles have been prepared via co-precipitation method and their structures were confirmed using Fourier transform infrared radiation (FT-TR), X-ray diffraction (XRD), scanning electron microscopic (SEM), and energy-dispersive analysis of X-ray (EDAX) analyses. Advantages of this efficient synthetic approach include higher purity and excellent yield of products, easy isolation of products and convenient manipulation.

کلیدواژه ها:

۱ ، ۳-Thiazoles ، Al۲O۳ nanoparticles ، Methylcarbonyls ، One-pot synthesis ، Heterogeneous catalyst