Prognostic factors for in-hospital mortality in neonates with Covid-۱۹: a cross-sectional study in south of Iran

Introduction: Due to high neonatal, maternal mortality and adverse pregnancy outcome, Covid-۱۹ in neonates is concerned. This study aimed to determine the prognostic factors for in-hospital mortality in neonates with Covid-۱۹.Methods: This retrospective cross-sectional study (February-November ۲۰۲۰) was performed on infected neonates (<۶۰ days) who were clinically diagnosed as Covid-۱۹ and were hospitalized in Covid-۱۹ wards in Shiraz University of Medical Sciences affiliated hospitals, southern Iran. Data were extracted from the patients' medical files, and were gathered in a data collecting form; including demographic characteristics, laboratory and clinical outcome. The patients were categorized as survivor and non-survivors groups, and then were compared.Results: Totally, ۹۶ neonates were enrolled. The mean±SD of age was ۱۳.۰۱±۱۰.۸۸ days, and most of them were in the age group of ۶-۱۵ days (۳۳.۳%). Fifty-nine (۶۱.۵%) was male. The mortality rate was ۱۲.۵%. Lower gestational age (P=۰.۰۳۱), and the more frequency of having underlying diseases (P=۰.۰۱۰) was observed in non-survivors. The most signs and symptoms were respiratory distress (۵۸.۳%), lethargy (۴۶.۹%), and poor feeding (۳۷.۵%). Pulmonary radiological involvement was more in non-survivors (P<۰.۰۰۱), and it was more severe in these patients (P<۰.۰۰۱). The results of Multivariate Logistic Regression Model showed that only receiving IVIG (OR=۲۰.۲, P<۰.۰۰۱) was the independent predictor factor for in-hospital mortality in these patients.Conclusions: The in-hospital mortality was obtained as ۱۲.۵% in the current study, and only receiving IVIG was the independent predictor factor for in-hospital mortality in neonates with Covid-۱۹.

کلیدواژه ها:

COVID-۱۹ ، Epidemiology ، Infant ، Mortality ، Prevalence ، Prognosis