Assessment of the Pro-oxidant Antioxidant Balance (PAB) in COVID-۱۹ Patients Compared to Healthy Subjects Referred to Masih Hospital

Objective: Recent studies have shown an increase in the pro-oxidant antioxidant balance (PAB) in patients with Covid ۱۹ and are also associated with exacerbation of clinical manifestations of the disease. What we focused on in the present study was the assessment of the status of PAB level in Covid ۱۹ disease. rMaterials & Methods: In this cross-sectional study, ۱۰۵ patients referred to Masih Hospital in Tehran in ۲۰۲۱, including ۵۸ subjects with COVID ۱۹ infection and ۴۷ as a control group were studied. The subjects in this study were evaluated for PAB by ELISA method.Results: The mean value of PAB in individuals with and without COVID ۱۹ was ۷۲.۷۷ ± ۱۷.۶۶ units and ۶۶.۵۳ ± ۱۴.۳۰ units, respectively, which was significantly higher in the first group (P =۰.۰۴۹). In patients with COVID ۱۹, there was a significant correlation between PAB and plasma triglyceride level (P=۰.۰۱۱) and there was an inverse relationship between PAB level and blood sodium level (P =۰.۰۴۷). In the subgroup of patients with COVID ۱۹, there was no significant relationship between PAB level and history of hypertension, hyperlipidemia, diabetes and ischemic heart disease.Conclusion: The increase in PAB is quite evident in patients with COVID ۱۹ compared to healthy individuals. There is a significant relationship between PAB and some laboratory markers in these patients such as blood triglyceride levels as well as decreased serum sodium. Therefore, it still seems that the

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Keywords: Covid ۱۹ ، PAB ، oxidative stress