Solvent free Synthesis of Novel ۹-(alkylthio)-Acenaphtho[۱,۲-e]-۱,۲,۴-triazine Derivatives

Polycyclic aromatic hydrocarbon (PAH) heterocycles are highly important structural units in avariety of pharmacologically active substances. At first glance, rigid polycyclic structures seemto have role in the development of antitumor agents owing to their ability in insertion betweenstacked base pairs of oligonucleotides and action as intercalator. Particularly important is thatwhen these planar polycyclic heterocycles bear appropriate side chains, further interactions withother important macromolecules might be envisaged [۱-۵].In the framework of our program to develop the chemistry of potentially bioactive heterocycliccompounds and in connection with our ongoing interests in this field, we represent here a facileprocedure for the solvent free synthesis of ۹-(alkylthio)-acenaphtho[۱,۲-e]-۱,۲,۴-triazines viatwo step condensation of thiosemicarbazide and acenaphtylene-۹,۱۰-quinone to formacenaphtho[۱,۲-e]-۱,۲,۴-triazine-۹(۸H)-thiones and subsequent reaction with benzyl chloridederivatives.