Nanoalumina sulfonic acid catalyzed rapid N-formylation undersolvent-free conditions

A rapid and chemoselective method for the N-formylation of structurally diverse anilineswith formic acid using nanoalumina sulfonic acid (NASA) at ۷۰oC under solvent-freecondition has been developed. The catalyst was found to be compatible with differentfunctional groups and the formylation proceeded smoothly with anilines bearing electronwithdrawing as well as electron donating substituents.

کلیدواژه ها:

Formamide ، Aniline ، Amino-protection ، Nanoalumina sulfonic acid