The effects of St. Thomas I and St. Thomas II Cardioplegia solutions on coronary sinus lactate in mitral valve surgery; A Randomized, Double-blinded, Clinical Trial

Background: Cardiac protection strategies in different methods are challenging and crucial, affecting postoperative morbidity and mortality.Objectives: We compared the cardio-protective effect of two cardioplegia solutions based on coronary sinus lactate levels.Methods:  This randomized, double-blinded clinical trial study was performed on ۴۶ candidates for mitral valve replacement between June ۲۰۲۰ and January ۲۰۲۱. The patients were categorized via block randomization method: ۱) St. Thomas I cardioplegia (n=۲۳) and St. Thomas Ⅱ cardioplegia (n=۲۳). The coronary sinus lactate levels at different times were measured. In addition, some intra-operative and clinical characteristics after cardiac surgery were recorded. Data were analyzed in SPSS software (version ۲۶.۰) using paired and independent t-tests, repeated measure ANOVA, and Pearson correlation test at a significance level of P < ۰.۰۵.Results: In the time trend, the lactate levels in patients with St. Thomas Ⅱ cardioplegia solution had a significantly lower rate than in St. Thomas I (P=۰.۰۰۱). The two groups displayed no statistical difference between the aortic cross-clamp time (P=۰.۰۶۹) and the CPB time (P=۰.۰۹۱). Furthermore, the weaning from mechanical ventilation (P=۰.۰۷۸) and ICU stay (P=۰.۰۶۱) demonstrated no statistical difference between the study groups.Conclusion: Based on significantly lower measures of the coronary sinus lactate, the St. Thomas Ⅱ cardioplegia solution showed a better cardio-protective effect in patients undergoing mitral valve surgery.

کلیدواژه ها:

Cardio-pulmonary Bypass ، Coronary Sinus ، Mitral Valve ، St. Thomas' Hospital cardioplegic solution