The Antibacterial Effects of Lithorex on the Growth of Bacteria: Multidrug-Resistant E. Coli

uropathogenic Escherichia coli (UPEC) is responsible for more than ۸۰% of UTI cases in humans. Due to the increasing resistance of pathogenic bacteria to atibiotics, the search for new alternatives to chemical drugs and antibiotics has recently become common. The therapeutic and medicinal effects of medicinal plants have been noticed for decades(۱)P. Theaim of this study was to investigate the effect of Lithorex drug on the growth ofEscherichia coli bacteria. Lithorex contains extracts such as Solidago canadensis andCucurbita pepo, which have antibacterial properties. Escherichia coli strains were isolatedfrom clinical samples and identified by diagnostic tests including gram staining, growthin triple sugar iron agar (TSI) media, and catalase assay. Antibiotic resistance pattern wasdetermined by disk diffusion method and minimum inhibitory concentration (MIC) wasdetermined by broth microdilution method. In order to investigate the antibacterial effectof Lithorex on Escherichia coli bacteria, clinical and standard strains of Escherichia coliwere treated with concentrations of ۱۰۰ and ۵۰ , ۲۵ of the drug.For this purpose, the disc diffusion method was used. The diameter of the halo without growth for the pathogenic strain of Escherichia coli was about ۱۳ mm .The results showed that the herbal medicine Lithorex has antibacterial properties, which, considering the global problem of antibiotic resistance, it is recommended to conduct more research in this field(۲).

کلیدواژه ها:

Escherichia coli ، Disc fusion ، Drug resistance ، Minimum inhibitory concentration