Evaluation of Cardiac Dysfunction in Children and Adolescents with Type ۱ Diabetes Mellitus

Background This study was conducted to identify cardiac dysfunction and the relationship of hemoglobin A۱c (HbA۱c) levels and serum lipids to echocardiographic indices in children and adolescents with T۱DM. Materials and Methods: This  case-control study was conducted on  ۱۰۰ cases  including ۵۰ children and adolescents aged ۳-۱۹ years old suffering T۱DM for at least  two years and ۵۰ age- and sex-matched healthy subjects with the patients. This study was conducted in Shahrekord, Iran. All participants underwent TDI echocardiography and the levels of HbA۱C and serum lipid were measured in diabetic patients. Then echocardio function of two groups were compared and the relation between these findings and HbA۱C and lipids was evaluated. Data was analyzed using SPSS software (version ۲۳.۰). Results: MPI, E/A, E'/A', E wave, A wave, IVRT, ET, EDV, LVIDd and LVIDs were significantly different between diabetes and control groups (p <۰.۰۵). However, EF, E/ E', IVCT, ESV and EF values showed no significant difference between diabetes and control groups (P>۰.۰۵). A significant, positive correlation was observed between E/E' and TG (p=۰.۰۰۷, r= ۰.۳۷). E/A showed positive correlation with HDL (p=۰.۰۴۶, r=۰.۲۸۴) and negative correlation with TG (p = ۰.۰۴۸, r=-۰.۲۸۱), and LDL (P=۰.۰۱۲, r=-۰.۳۵۲). E'/A' showed positive correlation with HDL (p=۰.۰۳۳, r=۰.۳۰۲), and negative correlation with TG (p=۰.۰۱۴, r=-۰.۳۴۷) in diabetic patients. Conclusion In diabetic patients, first, cardiac diastolic function decreases, resulting in a decrease in E¢/A and E/A ratios as well as a decrease in myocardial performance index, which indicates systolic and diastolic function, and is recommended to be taken into account in the initial examination of the heart of diabetics and not to wait for late-onset systolic function change.

کلیدواژه ها:

Children ، Diabetic cardiomyopathy ، Diabetes Mellitus ، Echocardiograph