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Recent progress in the intranasal PLGA-based drug delivery for neurodegenerative diseases treatment

محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 26، شماره: 10
سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 230

فایل این مقاله در 13 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/1738484

شناسه ملی سند علمی:

JR_IJBMS-26-10_001

تاریخ نمایه سازی: 4 شهریور 1402

چکیده مقاله:

One of the most challenging problems of the current treatments of neurodegenerative diseases is related to the permeation and access of most therapeutic agents to the central nervous system (CNS), prevented by the blood-brain barrier (BBB). Recently, intranasal (IN) delivery has opened new prospects because it directly delivers drugs for neurological diseases into the brain via the olfactory route. Recently, PLGA-based nanocarriers have attracted a lot of interest for IN delivery of drugs. This review gathered clear and concise statements of the recent progress of the various developed PLGA-based nanocarriers for IN drug delivery in brain diseases including Alzheimer’s, Parkinson’s, brain tumors, ischemia, epilepsy, depression, and schizophrenia. Subsequently, future perspectives and challenges of PLGA-based IN administration are discussed briefly.

کلیدواژه ها:

Drug Delivery ، Intranasal ، Nanoparticle ، Neurodegenerative diseases ، PLGA

نویسندگان

Nasim Aghaei Delche

Department of Biology, Payame Noor University, Tehran, Iran

Reyhaneh Kheiri

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of medical sciences, Tehran, Iran

Behnam Ghorbani Nejad

Department of Toxicology and Pharmacology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran

Mojgan Sheikhi

Department of Drug and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Malihe Sadat Razavi

Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran

Milad Rahimzadegan

Functional Neurosurgery Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Zahra Salmasi

Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

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