CRYSTALLIZATION AND SINTERABILITY BEHAVIOR OF BIORESORBABLE CaO-P۲O۵-Na۲O-TiO۲ GLASS CERAMICS FOR BONE REGENERATION APPLICATION

Abstract:Some types of glass and glass ceramics have a great potential for making bone tissue engineering scaffolds, drug carrier and bone cements as they can bond to host bone, stimulate bone cells toward osteogenesis, and resorb at the same time as the bone is repaired. Calcium phosphate glass ceramics have very attractive properties that allow them to use in bone tissue engineering. Calcium phosphate glasses could be used for the fabrication of resorbable constructs, with controlled biodegradability. This work was investigated crystallization and sinterability of biodegradable glass ceramics in the CaO–P۲O۵–Na۲O–TiO۲ system using differential thermal analysis (DTA), X-ray diffraction (XRD) and scanning electron microscopy (SEM). Sinterability of the glasses also was investigated by measurement of sintering parameters. Different thermal treatments were applied to control the degree of devitrification of glasses. In the developed glass ceramics Ca۲P۲O۷ were the first phase to precipitate in the mother glass structure, followed by Ca(PO۳)۲ and TiP۲O۷ at elevated temperature. Ca۲P۲O۷ and Ca(PO۳)۲ seem to have a very positive effect in bone formation in vivo. It is therefore expected that glass ceramics understudy have good potential to be used for bone regeneration applications

کلیدواژه ها:

Crystallization ، Sinterability ، Calcium Phosphate Glass ، Bioresorbable.