Novel pentoxifylline-loaded gel-nanofibers for burn wound healing

Introduction: Skin is a largest organ of body which protect body from different pathogen, regenerative medicine proposed new generation of smart wound dressing to accelerate wound healing and led to decrease significant burden on patients and healthcare systems. Here we describe assessment and characterization of novel nanofiber created by electrospinning machine from polyvinyl alcohol/gellan gum/polycaprolactone along with compound called pentoxifylline. Methods: amount of polyvinyl alcohol/gellan gum nanofibers containing drug were optimized in different concentration, then cross-linked for long stability. Topography characteristics were investigated with SEM and AFM imaging. Biocompatibility, degradation, swelling, and drug released survived by MTT and Spectrophotometry. Besides, contact angel, mechanical properties, water absorption and FTIR was carried out.Results: In this case study, results show that nanofiber is quite similar to extra cellular matrix and porous structure is suitable to traps the cells. Cross-linker importantly enhances the viscosity of linear gel by increasing the molecular simultaneously. Moreover, load of active agent is provided slow and continuous drug delivery. Swelling and contact angle test show gel-nanofibers moisturizes the surface of the dehydrated burn wound. Pentoxifylline delivery improves its efficacy by controlling the rate, time and place of release of drugs in the body. Conclusion: This study showed the ability of combination of polyvinyl alcohol/gellan gum/polycaprolactone in generation stable and well defined wound dressing which is also contain compound to increase wound healing process. Further study on preclinical and clinical setting may show the ability of healing effect as long as prevent scar formation and/or infection.

کلیدواژه ها:

Nanofiber ، Regenerative medicine ، wound ، Pentoxifylline