Comparison of Antidermatophytic and wound healing activity of Prosopis farcta,Chenopodium album and Apium nodiflorumExtracts

Introduction:Wound healing is a complex procedure with cellular and extracellular factorsand is a mainchallenges in the medical science. Dermatophytosis is a worldwidefungal disease in animals and humans,caused by dermatophytesspecies (pathogenic keratinolytic fungi). Some findingssuggest that someherbal extracts can progresswound healing through growth factors and its receptors.This study is aimed at examining the local effect of root extract of Prosopis farcta (P.farcta),Chenopodium album (Ch. apium),Apium nodiflorum (A. nodiflorum)extracts on wound healing and its antidermatophytic effect.Materials and Methods:According to the CLSI-M۳۸-A۲, in-vitro drugsusceptibility for aquatic extracts of P. farcta, Ch.album,A. nodiflorumand terbinafine were carried outagainstTrichophyton mentagrophytes.For in-vivo anti-dermatophytic activity, the nine male sprague rats wereinfected by T. mentagrophytis.The topical solutions (۱۰%) was formulated by root extract of herbs. The terbinafin (positive control) and solutions were topically applied thrice daily for ۱۵ days. The wound area was measured on day ۰, ۵, ۱۰ and ۱۵.Results:The MIC value of terbinafine was ≤ ۰.۲۵μg/mL against T. mentagrophytis. The MIC value of P.farcta, Ch. album and A.nodiflorumextractswere ۰.۵, ۰.۰۱۲۵ and ۰.۵respectively. The aquatic Ch. album extract showed the lowest MICvalues on fungal activity (with ۰.۰۱۲۵ µg/mL). The wound area in Ch. album group was significantly (۷۰%) reduced as compared to control group. The complete cure with aquatic root extractof Ch. album solutionlasted for ۱۵ days, compared to ۲۱ days with terbinafine.Conclusion:It seems that local administration Ch. album extractsprobably accelerates wound healing. It is hopeful thatCh. albummaybe an appropriate choice in traditional medicine and pharmacology.

کلیدواژه ها:

Wound healing ، Antidermatophyte ، Extracts