copper(II)-chitosan complexes as antibiotic-free antibacterial agent on wounds

Bacterial resistance to antimicrobial agents, especially antibiotics, is a challenge that has been recently recognized and addressed by the authorities all over the world as an emerging threat to humanity. The excessive use of antibacterial agents is causing a high impact on environment and all existing life mainly human being health. There is a worldwide trend to explore new alternatives that control postharvest pathogenic diseases, giving priority to methods that reduce disease incidence and avoid negative and side effects on human health. The chitosan, a polycationic biopolymer, is currently receiving a great deal of attention. It became a valuable compound undoubtedly due to its appealing intrinsic physicochemical and biological properties, such as biocompatibility, biodegradability and bioactivity.The antimicrobial activity of chitosan is well known against a variety of bacteria and fungi due to its polycationic nature. However, the antimicrobial activity of chitosan is sensitive to many factors such as molecular weight, pH, and water solubility. The chitosan, a polycationic biopolymer, is currently receiving a great deal of attention. It became a valuable compound undoubtedly due to its appealing intrinsic physicochemical and biological properties, such as biocompatibility, biodegradability and bioactivity. that low molecular weight chitosan exhibited strong bactericidal activities compared to chitosan with high molecular weight. The chitosan on the surface of the cell can from a polymer membrane, which prevents nutrients from entering the cell. Chitosan of lower molecular weight diffuses into the cell through pervasion. Sine chitosan could adsorb the electronegative substance in the cell and flocculate them, it disturbs the normal physiological activities of the bacteria and kills them.It can be observed that the antibacterial activities of Chitosan-Cu (II) complexes are enhanced with increasing chelate ratios. Ideal-inhibiting effects could be obtained when the chelate ratios of complexes were about ۱:۱. More works are needed to confirm this conclusion.Since chitosan degradation can be caused by the coordinating bond, we attempt to synthesize and characterize thechitosan-Cu (II) complex,and thereafter study the coordinating bond effect on its antibacterial activity against Salmonella enteritidis. Seven chitosan–copper complexes with different copper contents were prepared and characterized by FT-IR,UV-vis,XRD and atomic absorption spectrophotometry

کلیدواژه ها:

copper(II)-chitosan ، antibiotic-free ، antibacterial ، wounds