Role of silicate-based bioceramics in angiogenesis and accelerating the chronic wound healing process

Tissue engineering improves tissue healing and regeneration process using natural and synthetic materials. Although numerous treatments are developed for wound care management, prolonged and non-healing wounds require specific consideration. Chronic ulcer therapy still has remained a significant healthcare challenge. Chronic ulcers occur when healing fails to proceed within the anticipated time for example as a result of impaired blood supply. Chronic wounds are commonly related to ischemia, diabetes mellitus, venous stasis disease, or pressure. Four overlap phases are involved in the wound healing process, including hemostasis, inflammation, proliferation, and remodeling. Neovascularization is a vital key to wound healing acceleration in the granulation and remodeling phases of tissue regeneration. Generally, neovascularization in adults is associated with both angiogenesis and vasculogenesis and is a critical factor for appropriate and accelerating wound healing during whole phases of tissue repair. The angiogenesis process requires growth and survival-promoting factors, proteolytic enzymes, several differentiated and progenitor cell types, and appropriate microenvironments. Promoting wound angiogenesis or revascularization can lead to substantial advances in wound healing promotion. Silicate-based bioceramics such as diopside have the potential to induce angiogenesis and improve blood vessel formations. Recognizing materials enhancing angiogenesis would not only further advance our understanding of the regulating wound repair mechanism but also provide new approaches to overcoming the healing of chronic wound problems in vivo.

کلیدواژه ها:

Bioceramic ، Wound Healing ، Chronic Wounds ، vasculogenesis ، Angiogenesis