Burns are still one of the fundamental concerns of health care organizations due to their significant influences on patients' physical/mental status.
Burns themselves can have some serious and life-threatening effects in the acute phase, and on the other side, improper or insufficient treatment can be associated with infections, skin discoloration, psychological distresses, cosmetic issues, and many other complications. Despite the discovery of a diversity of therapeutic tools in this regard, a lack of more efficient therapeutic tools with more capabilities and free of adverse effects can be noticed, which recalls researchers for novel approaches. So far, MSC- based therapies have proven their ability in regeneration processes to aid wound repair in all its different stages. The transplantation of umbilical cord mesenchymal stem cells (UCMSCs) can be one of the ideal candidates because of their advantages like their easier accessibility and safe use besides their rich sources with higher proliferation/differentiation rates. Thus, we have evaluated the burn surface alterations in ۲۴ Wistar rats in two groups of UCMSCs and the control group to find out if UCMSCs can hasten the repairing process. Considering ethical guidelines and under sterile conditions, wounds were created after anesthetic steps. Thereafter, on days ۷, ۱۰, ۱۴, and ۲۱ burn surface was evaluated using the related formula to achieve wound repair percentage. The results have shown the statically significant strength of UCMSCs to accelerate wound repair in all of the evaluation days using the one-way analysis of variance (ANOVA) test (P Value <۰.۰۵). On day ۲۱, the healing percentage was near ۱۰۰% in the UCMSCs group, whereas the control group showed approximately ۶۵% that strongly emphasized on the successfulness of utilizing UCMSC for wound healing. Regarding the capabilities of UCMSCs in their nature and the remarkable potency of UCMSCs established by our study and several other similar works on animals, further clinical studies (in human beings in particular) and on larger scales seem to lead to satisfactory results. Also, histopathological features of burns could be included in future studies to indicate UCMSCs’ effects on different wound healing properties.