Naringenin improves the healing process of burned skin damage in rats

Burn wounds is a complex and dynamic process that begins immediately after tissue injury and continues until the wound has healed and been remodeled. Applying the most effective methods of burn repair is an ongoing challenge in medicine. Recent investigations and animal studies demonstrate that Naringenin has Phenol compounds and flavonoids are documented to possess anti-inflammatory and antioxidant activities, and the flavonoid naringenin is proposed to have pharmacologically significant effects against including anti-ulcerogenic and wound healing effects. The present study was planned to evaluate the possible burn wound healing effect of narengenin in rats. Material and methods: In this experimental study, ۴۰ male Wistar albino rats were examined in five groups of eight receiving silver sulfadiazine cream ۱% (reference standard), eucerin (positive control), ۵% and ۱۰% ointments of naringenin (treatment groups) for ۱۴ days. Negative control group received no treatment. Burn wounds were made on the dorsal part of the animals' necks. Wound contraction rate and histopathologic study of wound sites after sacrificing the rats were performed. Data were analyzed using SPSS software version ۲۲. Results: On the ۱۴th day, wound contraction rate (WCR) was significantly higher in rats treated with naringenin ۱۰% extract ointment compared with ۵% extract, positive and negative control groups (P < ۰.۰۰۱) and SSD (P=۰.۰۱). Application of ۱۰% extract ointment on burn wound sites showed complete healing and slight tissue inflammation and edema.Conclusion: These results suggest that the naringenin could accelerate the wound healing process. Further study is required to identify the compounds responsible for its wound healing properties and to understand the mechanism of action.

کلیدواژه ها:

burn wound ، narenginin ، rat ، animal ، cream