Comparison of the effect of Nano Ostrich Eggshell and Hydroxyapatite on Bone Defect Healing in Rat Calvaria
محل انتشار: مجله تروما، دوره: 25، شماره: 6
سال انتشار: 1399
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 110
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شناسه ملی سند علمی:
JR_TRAUM-25-6_002
تاریخ نمایه سازی: 13 مرداد 1402
چکیده مقاله:
Background: Fracture healing is important in medicine; thus seeking new techniques with fewer side effects to improve the speed of the healing is prudent. Objectives: This experimental study sought to assess the effect of the nano ostrich eggshell (N-OES) and hydroxyapatite (HA) composite on bone defect healing in rat calvaria. Methods: In this study, a ۷-mm bone defect was created in the calvaria of ۴۵ male Sprague–Dawley rats. The animals were randomly divided into three groups, and the defects in each group were filled with N-OES, HA, or as a control group. The animals were euthanized and histological and serological assessments were carried out at ۱۴, ۲۸ and ۴۲ days after the operation. Results: At ۱۴ and ۲۸ days after the operation, in the edges of the defect, there was a significant difference between the treatment and control groups (p ≤ ۰.۰۵). However, there were no statistically significant differences between N-OES and HA treatment groups (p > ۰.۰۵). At this time, in the center of the defect, there was a statistically significant difference between the N-OES group with HA and control groups (p ≤ ۰.۰۵). On day ۴۲, no significant difference in the edges of the defect was observed between all groups. However, there was a statistically significant difference in the center of the defect between the N-OES group with HA and control groups (p ≤ ۰.۰۵). Results of the serological assessment indicated that the applied treatments increased the serum levels of alkaline phosphatase. Conclusions: The results of this study indicate the potential efficacy of nano ostrich eggshell as a bone substitute in rat calvaria defects.
کلیدواژه ها:
نویسندگان
Roya Rezaeian
Department of Clinical Sciences, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran
Hamid Reza Moslemi
Department of Clinical Sciences, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran
Mahmood Ahmadi Hamedani
Department of Clinical Sciences, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran
Sahar Ghaffari Khaligh
Department of Pathobiology, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran