Grading of Glioma Tumors by Analysis of Minimum Apparent Diffusion Coefficient and Maximum Relative Cerebral Blood Volume

Background: Gliomas are the most common primary neoplasms of the central nervous system. Relative cerebral blood volume (rCBV) could estimate high-grade Gliomas computed with dynamic susceptibility contrast MR imaging which it is artificially lowered by contrast extravasation through a disrupted blood-brain barrier. Objectives: Our intent was to clarify the usefulness of diffusion-weighted magnetic resonance imaging (DWI) and perfusion weighted magnetic resonance imaging (PWI) in the grading of Gliomas. Materials and Methods: Both PWI and DWI with a three-tesla scanner investigated nineteen consecutive patients with Gliomas. The means of rCBV and ADC values have been compared among the tumor groups with t-test and ROC curve analysis to determine threshold values of Gliomas grading. Results: Mean maximum rCBV were ۲.۷۱±۱.۴۱ for low grades (I & II), and ۸.۱۴±۲.۵۸ for high grades (III & IV) Gliomas (p=۰.۰۰۱). Mean minimum ADC were ۱.۴۷±.۴۶ ×۱۰۳ mm۲/s for low grades (I & II), and .۴۷±.۳۸×۱۰۳ mm۲/s for high grades (III & IV) Gliomas (p=۰.۰۰۱). We can get ۰.۹۴×۱۰۳ mm۲/s for minimum ADC and ۳.۸۵ for maximum rCBV as a difference cutoff point between low and high-grade Gliomas. Conclusion: Combination of both DWI and PWI techniques, with measurement of minimum ADC and maximum rCBV can be used to distinguish between high grade and low-grade Glioma tumors.

کلیدواژه ها:

Diffusion Magnetic Resonance Imaging ، Neoplasm Grading