Background and aims: Healthcare institutes, including hospitals, need a structured electronicmedical record for timely access to patient data, and for this purpose, hospital information systemsare designed. This study aims to design and develop a web-based hospital information system tomanage hospital information system processes, provide quick access to information, improve patientsatisfaction, and create an effective decision support system for health care providers.Method: A program based on web technology was created to manage the medical records of hospitalizedand monitored patients. Some parts of this system include visiting actions of patients,tracking patient records in different hospital and paraclinical sections, defining the access of staffand physicians, providing management reports, aggregation of information at the university level,management of basic information and system coding in a centralized form of headquarters, standardoutputs such as Excel and PDF, use of coding systems, standard terminology and ontology,electronic archive of medical records, generating electronic forms, as well as managing paraclinicaland pharmacy in Mashhad Velayat hospital. One of the features of the designed HIS is the possibilityof managing and recording information in a headquarters by the related units in the headquarters,and the hospital user can only use the information in Read only form. The methodologyused in the production and development of software is Scrum. This method is an iterative modelof Agile methodology for managing software projects, which provides the possibility of providinga quality product with the efficient management of the software production and development process.The architecture used in the project is Service Oriented Architecture (SOA). Supply requiredinfrastructure web-based hospital information system has been done (including cloud Wi-Fi, tablets,installing voice-to-text software, etc.). In order to implement, modern web-based softwareproduction technologies have been used including Angular ۸, .net Core, SQL Server, power bi ،and Tableau, its design is responsive and it can be used on all types of hardware devices such astablets and mobile phones. The patient’s electronic record that created by the hospital informationsystem can be presented to other organizations (such as forensic medicine, insurance, etc.)and within the organization (between hospitals and headquarters units). The interoperability withother systems and services including sending, receiving and managing communication with otherinternal or external systems and related systems such as PACS, LIS, etc. is done through WebAPI. The developed system has a user-friendly graphical interface and provides features such asInternet access and complete electronic patient records and remote access that can be downloadedfrom a web server and run by a browser. This system is based on HL۷ global standards andinternal standards of the Ministry of Health (SEPAS (and has CPOE and CDSS of diagnostic andtherapeutic type and is also integrated with other information systems such as Packs, LIS, medicalequipment, and portable tools (barcode reader, tablet, kiosk, etc.).Results: The use of this web-based hospital information system has led to improving the qualityof health care provision, reducing hospital costs, improving time management, increasing educationalcapabilities, and improving access to remote patient records. Also, this system has in creased the satisfaction of patients and physicians by reducing waiting time through high-qualityinformation infrastructure and systems.Conclusion: The successful establishment of a web-based hospital information system, consideringthe provision of patient medical records without time and space limitations in all parts of thehealth system, from the point of view of physicians and other health care providers, can improvethe organizational performance of the hospital.