Diagnostic Role of Platelet-Lymphocyte Ratio and Platelet Parameters in COVID-۱۹ Disease

Backgrounds: This study aimed to analyze the applicability of platelet parameters in assessing the severity of COVID-۱۹ disease. Materials & Methods: Patients with RT-PCR confirmed COVID-۱۹ in the pathology department of a tertiary care hospital in south India from June to December ۲۰۲۰ were included in this study. Clinical details and laboratory parameters of these patients were obtained. The difference between the studied variables in two groups was assessed using independent t-test. The optimum cut-off value of platelet to lymphocyte ratio (PLR) to differentiate between the tested groups was estimated using ROC (receiver operator curve) analysis. Findings: This study was conducted on ۲۱۸ COVID-۱۹ patients, of whom ۱۷.۹% showed thrombocytopenia at the time of admission. Among the hematological parameters, PLR, absolute lymphocyte count (ALC), platelet distribution width (PDW), D-dimer, and erythrocyte sedimentation rate (ESR) were significantly different between the ICU (intensive care unit) and non-ICU groups. Increased PLR values were associated with the disease severity. Conclusion: PLR could be used as an additional biomarker in assessing the severity of COVID-۱۹ disease, and a cut-off value of ۲۱۰.۲۷ is optimal to differentiate severe COVID-۱۹ disease from its mild and moderate forms with ۷۹% specificity.

کلیدواژه ها:

Biomarker ، COVID-۱۹ ، Intensive care unit