Nanocapsulation of Lemongrass essential oil into herbal gel and evaluation of its antifungal activity against Candida albicans

Plant essential oils, because they contain bioactive compounds,۱ have many biological activities such as antibacterial, antiviral and antifungal.۲ But due to their low solubility in water and degradation due to environmental factors, their biological activities have limitations. To solve this problem, it is possible to protect essential oils by encapsulating them and increase their effectiveness.۳ The aim of this study is to produce and identify Alyssum homolocarpum gel loaded with lemongrass essential oil, to evaluate its release and anti-candidacy activity. Alyssum homolocarpum gels loaded with lemongrass essential oil was produced by nanoemulsion method and were identified according to morphological and physicochemical parameters, encapsulation efficiency and release characteristics. This nano gel was characterized using infrared spectroscopy (IR) and field emission scanning electron microscopy (FESEM). Their anti-candidacy activity was measured by broth microdilution method. These results show that Alyssum homolocarpum gel loaded with lemongrass essential oil can be used as an anti-albicans agent.

کلیدواژه ها:

Alyssum homolocarpum ، Candida albicans ، Encapsulation ، Essential oil ، Lemongrass