An evaluation of the antifungal and antimicrobial properties of some novel chromenopyrimidinones

Chromenopyrimidinones (CPOs) are a class of chemical compounds that exhibit antitumor effects on Hepatocellular Carcinoma (HCC), a type of liver cancer. CPOs can suppress the expression of CD۱۳۳, a marker of cancer stem cells (CSCs) that are responsible for tumor maintenance and progression [۱]. CPOs can also inhibit the activity and expression of DNA methyltransferases (DNMTs), enzymes that regulate DNA methylation, an epigenetic mechanism that affects gene expression. The purpose of this study is to prepare novel substituted CPO heterocycles that display a broad spectrum of biological activity. In this work new CPO derivatives (۵) were designed and synthesized via cyclization of pyranopyrimidinone derivatives (۴) with various carboxylic acids under reflux conditions [۲]. Analyses such as ۱H and ۱۳C NMR, mass, and infrared spectrometry were conducted to verify the structure of the prepared compounds ۵. All synthesized compounds have been tested for their potential biological activities, such as antibacterial and antifungal properties. Strains of bacteria, Staphylococcus aureus, and Streptococcus pyogenes, that are Gram-positive; Escherichia coli and Pseudomonas aeruginosa, which are Gram-negative; and Aspergillus niger as fungal strains were used for in vitro studies.

کلیدواژه ها:

Antifungal activity ، Antimicrobial activity ، Chromenopyrimidinone ، Multicomponent Reaction ، Pyranopyrimidinone