Human Plasmodium in Livestock: The Absence of PfHRP۲ and pLDH Among High Parasitemia Cases
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 101
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شناسه ملی سند علمی:
JR_IJMPES-2-2_004
تاریخ نمایه سازی: 28 تیر 1402
چکیده مقاله:
Introduction: Plasmodium falciparum and Plasmodium vivax are reported to have infected domestic cattle as buffalo, horses, dogs, and goats in Sumba, along with Etawa crossbreed goats in Purworejo. One of the markers of human-Plasmodium (h-Plasmodium) invasion in the erythrocyte phase is the appearance of PfHRP۲ and parasite lactate dehydrogenase (pLDH). This study aimed to detect h-Plasmodium using PfHRP۲-pLDH-based rapid diagnostic test (RDT) in the blood of Etawa crossbreed goats that were tested positive for microscopic infection.
Methods: A cross-sectional study was conducted in a malaria pre-elimination area in Purworejo District, Indonesia. Livestock blood sampling was performed on a population of goats within a radius of ۳۰۰ meters from the residence of malaria cases.
Results: The presence of h-Plasmodium was detected by Rapid Diagnostic Test (RDT) Monotes Malaria for PfHRP۲-pLDH. The mean parasitemia level of h-Plasmodium on Etawa crossbreed goats was ۳۰۶۱ parasites/μL of blood. No cases were detected positive using RDT Monotes Malaria from four goats that were microscopically positive for h-Plasmodium.
Conclusion: The PfHRP and pLDH-based RDT methods for the detection of h-Plasmodium indicated that they are not sensitive to be applied to animal blood. Other immunological detection methods are needed to determine the activity of h-Plasmodium when it invades animal red blood cells.
کلیدواژه ها:
نویسندگان
Didik Sumanto
Faculty of Public Health, Universitas Muhammadiyah Semarang, Indonesia- Faculty of Medicine, Universitas Diponegoro Semarang, Indonesia
Suharyo Hadisaputro
Faculty of Medicine, Universitas Diponegoro Semarang, Indonesia
Mateus Sakundarno Adi
Faculty of Public Health, Universitas Diponegoro Semarang, Indonesia- Magister of Epidemiology, Universitas Diponegoro Semarang, Indonesia
Siti Susanti
Faculty of Public Health, Universitas Muhammadiyah Semarang, Indonesia