Antimicrobial Effect of Ficus carica on Nosocomial Bacterial Infections
محل انتشار: مجله تحقیقات دارویی ابن سینا، دوره: 2، شماره: 2
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 143
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شناسه ملی سند علمی:
JR_AJPR-2-2_006
تاریخ نمایه سازی: 28 تیر 1402
چکیده مقاله:
Background: The incidence of drug resistance against chemical antimicrobial drugs has directed the
attention to the use of medicinal plants in the treatment of infections. This study aimed to evaluate the
antimicrobial activity of Ficus carica extracts against pathogenic bacteria, especially nosocomial infections.
Methods: In this experimental study, aqueous and alcoholic extracts of F. carica were extracted. This
study investigated inhibitory effects of plant extracts against pathogenic bacteria such as Staphylococcus
saprophyticus, Escherichia coli, Salmonella typhimurium, and Proteus mirabilis as well as pathogenic
nosocomial including Staphylococcus aureus, Klebsiella pneumonia, Acinetobacter, and Pseudomonas
aeruginosa through disk diffusion methods, well diffusion method, and microdilution. Serial dilutions
of the extracts were prepared in the range of ۵۰ to ۱۰۰۰ mg/mL to determine the minimum inhibitory
concentration.
Results: The aqueous extract of the plant showed higher inhibitory effects against microbial strains
compared to the alcoholic extract. The two strains of S. saprophyticus and S. aureus indicated greater
susceptibility than extracts (e.g., aqueous, methanol, and ethanol). Statistically, there was a significant
difference in the minimum inhibitory concentration of aqueous extract growth compared to alcoholic
extracts. The aqueous extract had a minimum inhibitory concentration of ۱۳۳ mg/mL and a minimum
bactericidal concentration of ۲۰۰ mg/mL on gram-positive bacteria of S. saprophyticus and S. aureus,
respectively.
Conclusion: The study found F. carica that extract had significant effects on microorganisms of two grampositive
bacteria including S. saprophyticus (۶۲ mm in diameter) and S. aureus (۶۰ mm in diameter), and
the bacterium P. aeruginosa revealed the highest resistance against gram-negative bacteria. The extracts
also indicated significant effects compared to the antibiotics as a control. Although further research is
needed in this regard, F. carica extract can be suggested as a new antimicrobial agent in medical research.
کلیدواژه ها:
Medicinal plant extract ، Pathogenic bacteria ، Minimum inhibitory concentration ، Digestive and skin disease
نویسندگان
Shayda Jabbari
Department of Biotechnology, Faculty of Biological Sciences and Technology, Shahid Ashrafi Esfahani University, Esfahan, Iran
Maryam Sadat Mirbagheri Firoozabad
Department of Biology, Yazd University, Yazd, Iran