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Reversing the Warburg effect to control cancer: a review of diet-based solutions

سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 141

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شناسه ملی سند علمی:

JR_JCOMS-2-3_001

تاریخ نمایه سازی: 28 تیر 1402

چکیده مقاله Reversing the Warburg effect to control cancer: a review of diet-based solutions

Warburg effect is a form of cellular metabolism commonly used by cancer cells, in which, consumption of glucose and production of acidic cell metabolic wastes take place at a considerably higher rate. The effect is well described in the literature, however, the applications for cancer prevention and treatment have not been resolved effectively yet. According to the Warburg effect, anaerobic cellular respiration and the resulting acidic cellular environment are linked to the development of cancerous tumors. But an oxygen-rich environment with optimum alkalinity at the cellular level can result in retaining healthy cells and inhibiting cancer cell growth. As an alternative or complementary solution for cancer treatment based on the Warburg effect, a healthy balanced diet with alkalizing (but not alkaline) properties helps maintain acid-base balance in the body and also provides optimum metabolic rate and sufficient hydration for more effective health improvement. This paper presents a review of the key concepts related to links between cancer and dietary and environmental factors, with the main focus on the Warburg effect and energy metabolisms in cancer cells. In addition, some practical diet-based solutions are summarized that may potentially control cancer by utilizing the reversed Warburg effect by which, optimum pH levels and sufficient oxygenation may be provided at the cellular level.

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نویسندگان مقاله Reversing the Warburg effect to control cancer: a review of diet-based solutions

Hassan Bahrami

Independent Health/Nutrition Researcher

Majid Tafrihi

Molecular and Cell Biology Research Laboratory, Department of Molecular and Cell Biology, Faculty of Sciences, University of Mazandaran, Babolsar, Iran

Soraya Mohamadzadeh

Department of Biology, Faculty of Science, University of Zanjan, Iran