Effects of hydrogels based on lipid-based nanoparticles (LNPs) in the treatment of glioblastoma: A systematic review, meta-analysis and meta-regression

Introduction: Glioblastoma (GBM) is the most common malignant brain tumor in adults. Among all types of cancer, glioblastoma is more resistant to chemotherapy and radiation therapy. Treatment of this disease is difficult due to its malignancy, rapid progression, and high resistance to anticancer drugs. Considering the high resistance of glioblastoma tumor to chemotherapy and radiotherapy and the impracticality of complete tumor removal by surgery due to the invasive nature of the tumor, a new attention and attitude towards nanomedicine has been created. The present study is a systematic review, meta-analysis and meta-regression study with the aim of investigating the effects of hydrogels based on lipid-based nanoparticles (LNPs) in the treatment of glioblastomaMaterials and methods: In this study, searching was conducted in Scopus, Web of science, Pubmed, PLUS ONE and Google Scholar search engines. In the search of keywords such as lipid-based nanoparticles, glioblastoma, Hydrogel along with their Mesh terms, were done without time limit. The search was done according to the PRISMA protocol. ARRIVE and CRIS checklists was used to check the quality of compliance. Egger's Test of the Intercept was used to check publication bias.Results: After searching, ۱۳۹ articles were found. Out of the ۱۳۹ articles found, ۸ articles were removed due to duplication, out of the remaining ۱۳۱ articles, ۱۱۵ articles were removed due to irrelevance and ۱۰ articles were removed due to lack of access to the full text of the article, so finally ۶ studies were included in the meta-analysis process.Conclusion: Hydrogels based on lipid-based nanoparticles (LNPs) cause drug specificity in better targeting of cancer cells for glioblastoma treatment. Also, these hydrogels cause controlled and long-term drug release in the target tissue.

کلیدواژه ها:

drug delivery ، lipid-based nanoparticles ، glioblastoma ، hydrogel