Investigating the Effects of Pethidine on Hemodynamic Status after Completion of Laparotomy Surgery

Introduction: The objective of the study was to assess and compare the analgesic effectiveness and safety profiles of pethidine in relieving pain experienced post major surgical procedures. Material And Methods: A prospective interventional investigation was carried out on a cohort of ۷۱ patients who underwent a significant surgical procedure. In this study, a total of ۷۱ patients were administered intramuscular medication for a duration of ۴۸ hours following surgery. Specifically, ۳۶ individuals were treated with placebo dosages of ۳ CC administered at ۶-hour intervals, whereas the remaining ۳۵ received ۱۰۰ mg doses of pethidine at the same frequency. The present study aimed to evaluate and compare the analgesic efficiency and safety of placebo and pethidine. The aforementioned evaluation was performed at various time intervals of ۱, ۶, ۱۲-, ۲۴-, ۳۲-, and ۴۸-hours post-administration of the respective drugs. The efficacy of analgesics was evaluated through the utilization of both the Visual Analogue Scale (VAS) and Verbal Rating Scale (VRS). Results: The present study demonstrated the equianalgesic efficacy between placebo and Pethidine as determined by both Visual Analogue Scale (VAS) scores at ۱۲ and ۴۸ hours, and Verbal Rating Scale (VRS) scores at ۱ and ۴۸ hours during the postoperative period. During alternative observation periods, it was observed that pethidine demonstrated superior analgesic properties when compared to ketorolac. Conclusion: Pethidine demonstrated a higher degree of efficacy as an analgesic agent in comparison to ketorolac. Additional investigations, comprising a double-blind randomized trial, have been proposed to authenticate the findings presented in the current undertaking.

کلیدواژه ها:

Pethidine ، Hemodynamic ، laparotomy ، Post-Operative