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Serum Amyloid A (SAA) as Early Diagnosis of COVID-19 Disease: A Systematic Review and Meta-Analysis

سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 198

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شناسه ملی سند علمی:

JR_IJMM-17-2_001

تاریخ نمایه سازی: 18 تیر 1402

چکیده مقاله Serum Amyloid A (SAA) as Early Diagnosis of COVID-19 Disease: A Systematic Review and Meta-Analysis

Background and Aim: In December 2019, human-to-human transmission of respiratory illness (pneumonia) with fever and sputum was discovered in the respiratory tract, called COVID-19. Serum amyloid A (SAA) is an acute-phase plasma protein that is considered to be diagnostically superior to CRP in pathological conditions such as viral diseases. Therefore, the study question in this review is whether SAA as an indicator is involved in the early diagnosis of COVID disease. Materials and Methods: To identify related studies, we systematically searched international databases, including PubMed, Scopus, Science Direct, Cochrane, Embase, Web of Science, and Google Scholar search engine, without restriction on time until June 2021. Also, the Reference list of relevant studies was reviewed separately to find all existing articles in this field. Summary standardized mean difference (SMD) was estimated using random effects meta-analysis. Results: A total of 394 potentially relevant articles were identified from the initial search. After removing the duplicates and reading the title, abstract and full-text review, six studies were entered into the meta-analysis. There was a significant difference between the means of SSA among patients with a severe form of the disease compared to non-sever groups (SMD=-0.91, 95% CI: 1.18-1.59, -0.23) and with the control group (SMD=4.68, 95% CI: 1.18, 8.18). The Beggs and egger test results indicated no evidence of publication bias in the reported SMD. Conclusion: The result of our work indicates that SAA might potentially be used for the early diagnosis of COVID disease, but more studies are needed.

کلیدواژه های Serum Amyloid A (SAA) as Early Diagnosis of COVID-19 Disease: A Systematic Review and Meta-Analysis:

Early Diagnosis ، COVID-19 disease ، SAA ، Serum amyloid A protein ، پروتئین سرم آمیلوئید A ، تشخیص زودهنگام ، بیماری کووید 19

نویسندگان مقاله Serum Amyloid A (SAA) as Early Diagnosis of COVID-19 Disease: A Systematic Review and Meta-Analysis

Iman Owliaee

Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran

Nastaran Saadat

Department of Virology, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran

Shahab Mahmoudvand

Department of Medical Virology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

Hossein Vakilimofrad

Department of Medical Library and Information Sciences, School of Paramedicine, Hamadan University of Medical Sciences, Hamadan, Iran

Salman Khazaei

Research Center for Health Sciences, Hamadan University of Medical Sciences, Hamadan, Iran

Nastaran Ansari

Department of Medical Virology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

Razieh Amini

Molecular Medicine Research Center, Hamadan University of Medical Sciences, Hamadan, Iran

Farid Azizi Jalilian

Department of Medical Virology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

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