Breast Carcinoma; Human Epidermal Growth Factor Receptor-۲ (HER-۲) and Grading Correlation

Introduction: Overexpression of Human Epidermal Growth factor Receptor-۲ (HER-۲) is one of the most important prognostic and predictive factors of breast cancer, observed in ۲۵% - ۳۰% of breast carcinoma patients leading to poor prognosis and feasible anti HER-۲ antibody drugs. The objective of this study was to evaluate the HER-۲ frequency in target population and its correlation with histologic grade as well as tumor pathology, estrogen receptor (ER) and P۵۳ in our patients. Methods: A total of ۳۰۰ cases (all female) aged ۲۴- ۸۰ year, were randomly selected from patients who were admitted in two of the Tehran University of Medical Sciences affiliated centers (Emam Khomeini Cancer Institute and Shariati hospital) over a ۲-year period (۲۰۱۳-۲۰۱۴). Assessment of tumors for HER-۲, P۵۳, ER, pathological type and histologic grade was performed. HER-۲ over expression defined as three plus (+++) in immunohistochemistry (IHC). Results: The mean age was ۴۹.۶±۱۱ years. HER-۲ over expression was seen in ۳۴% of the patients. Significant correlations were found between HER-۲+, P۵۳+ and high histologic grade and ER (P<۰.۰۵). However, there was no significant correlation between HER-۲ and pathologic type of tumors in our study. Conclusion: Co-expression of several poor prognostic biomarkers in breast cancer (HER-۲ +, P۵۳ +, ER- , high grade) may predict more aggressive phenotype, worse disease and lower overall survival in these patients.

کلیدواژه ها:

Breast carcinoma ، Tumor Grading ، Human Epidermal Growth Factor Receptor-۲ (HER-۲)