A comprehensive review of Ebola virus: as a global health threat

The greatest Ebola virus disease (EVD) epidemic in recorded history is now occurring in West Africa. The Zaire Ebolavirus (EBOV), the virus responsible for this outbreak, is a member of the genus Ebolavirus, which combined with the genus Marburgvirus makes up the family of the Filoviridae. Among the viral hemorrhagic fevers, EBOV is one of the most aggressive viruses; case fatality rates of up to ۹۰% have been documented. Multi-organ failure and serious bleeding problems are what cause death. The WHO recorded ۵۳۳۵ cases (confirmed, suspected, and probable) as of September ۱۸th, ۲۰۱۴, with ۲۶۲۲ fatalities, yielding a case fatality rate of almost ۵۰%. With a focus on pathophysiology, clinical symptoms, and therapeutic options, this review aims to provide an overview of EVD for clinicians.

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Keywords: Ebola virus disease ، Pathogenesis ، Diagnosis ، treatment ، filovirus