Comparison of Fentanyl and Midazolam for the Sedation of Infants Under Mechanical Ventilation; A Randomized Clinical Trial
سال انتشار: 1396
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 71
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شناسه ملی سند علمی:
JR_HPR-2-3_002
تاریخ نمایه سازی: 6 تیر 1402
چکیده مقاله:
Background: Neonatal respiratory distress syndrome (NRDS), a life-threatening pulmonary disorder, involves ۱% of all deliveries worldwide. Shallow breathing causes restlessness in infants, which itself affects pulmonary function; thus, sedative medications are used to preserve better pulmonary function. There are different opinions about the benefits and superiority of these drugs. Objective: The study purposed to assess and compare the effects of fentanyl and midazolam on the required time of mechanical ventilation in infants with respiratory distress syndrome (RDS). Methods: In this randomized clinical trial, ۶۰ infants with RDS were randomly allocated to ۲ groups (۳۰ infants each); the first group underwent sedation with midazolam (۰.۱ mg/kg), and the second group received ۰.۵ mcg/kg of fentanyl during ventilation. The duration of hospitalization, required time of ventilation, drug complications, feeding intolerance, as well as pneumothorax incidence and need for re-intubation were recorded and compared between the ۲ groups. Results: Eventually, ۶۰ infants (۴۵ male and ۱۵ female) with a mean gestational age of ۳۷.۱۳±۱.۲۲ weeks in the midazolam group and ۳۶.۷۳±۱.۵۰ weeks in the fentanyl group underwent analysis (P value=۰.۴۴۹). Infants in the midazolam group had a mean length of stay of ۱۱.۹۶ ± ۳.۴۱ days, while mean length of stay was ۱۰.۳۶±۳.۵۷ days for infants in the fentanyl group (P value=۰.۰۳۹). Mean duration of mechanical ventilation was ۴.۶±۲.۱۴ days in the midazolam group and ۴.۰۶±۲.۰۴ days in the fentanyl group (P value=۰.۲۵۲). Conclusion: The findings suggest that midazolam is a more suitable medication for the sedation of infants under mechanical ventilation in comparison with fentanyl; however, its side effects, such as apnea, pneumonia, and seizure, should be considered.
کلیدواژه ها:
نویسندگان
Bita Najafian
Department of Pediatrics, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
Bahareh Esmaeili
Department of Clinical Pharmacy, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
Mohammad Hossein Khosravi
Student Research Committee (SRC), Baqiyatallah University of Medical Sciences, Tehran, Iran
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