Fresh embryo transfer in the cleavage and blastocyst stages and pregnancy outcomes: A retrospective cross-sectional study

Background: Advances in cell culture media have led to a trend of embryo transfer from the early cleavage stages to blastocyst stage. Objective: The study aims to compare the effects of fresh embryo transfer in cleavage and blastocyst stage on pregnancy outcomes. Materials and Methods: This cross-sectional study was conducted on ۱۴۲۲ cases referred to the Umm-al-Banin Infertility Clinic Center, Dezful, Iran, between July ۲۰۱۳ and December ۲۰۲۰ who were candidates for in vitro fertilization/ intracytoplasmic sperm injection for fresh embryo transfer. A total of ۱۲۴۶ cases were divided into ۴ categories on days ۲-۵ or ۶. Chemical and clinical pregnancy, abortion, multifetal pregnancy, ongoing pregnancy, and live birth rates were analyzed. Results: Fresh embryo transfer was performed in ۲۸.۵% of the cases on the ۲nd day, ۴۵.۸% on the ۳rd, ۱۵.۳% on the ۴th day, and ۱۰.۴% on days ۵ or ۶. The overall clinical pregnancy and live birth rates were estimated at ۲۰.۶% and ۱۷.۶% in the cleavage, and ۱۷% and ۱۴% in the blastocyst stages, respectively. However, no significant difference was observed in either group. In addition, there was no significant difference between groups in terms of the abortion, multifetal pregnancy, and ongoing pregnancy rate (p ˃ ۰.۰۵). Conclusion: According to the results, the consequences of pregnancy in fresh embryo transfer at the blastocyst stage were not superior to embryo transfer at different stages of the cleavage process.

کلیدواژه ها:

Embryo transfer ، Cleavage ، Blastocyst ، Pregnancy outcomes. ، انتقال جنین ، کلیواژ ، بلاستوسیست ، پیامدهای بارداری.