Vitamin C modulates adrenaline-augmented gastric injury via cardiac troponin/creatine kinase pathway in Wistar rats

Objective(s): Vitamin C has anti-oxidant benefits in the gastrointestinal tract and heart. This study investigated the effect of vitamin C on some gastric parameters in myocardial injury in rats. Materials and Methods: Thirty Wistar rats were divided into five groups (n = ۶). Group ۱ was the control and Group ۲ (ADR) received ۱ mg/kg of adrenaline subcutaneously on days ۱۳ and ۱۴. Group ۳ received vitamin C (۲۰۰ mg/kg) orally for ۱۴ days. Group ۴ received adrenaline (۱ mg/kg) on days ۱ and ۲ and vitamin C from days ۱ to ۱۴. Group ۵ received vitamin C till day ۱۴ and adrenaline on days ۱۳ and ۱۴. All animals were sacrificed after ۲ hr of pyloric ligation. Gastric secretion parameters were assessed while a blood sample was obtained for biochemical analysis. Results: Gastric juice volume, total gastric acidity, pepsin activity, cardiac troponin ۱, creatine kinase-MB, and lactate dehydrogenase levels increased (P<۰.۰۵) in ADR only group relative to the control. Pre- and post-vitamin C treatment reduced (P<۰.۰۵) these markers to near normal. However, treatment with vitamin C reduced (P<۰.۰۵) ulcer score, and increased (P<۰.۰۵) pepsin activity, mucus weight, and serum vitamin C levels when compared with the ADR-only group. Pre-treatment with vitamin C resulted in a marked decrease (P<۰.۰۵) in gastric juice volume, pepsin activity, and total gastric acidity compared with post-treatment in the adrenaline-induced injury group.Conclusion: Vitamin C pretreatment reduces excessive gastric secretions, ulcer scores, and attenuates cardio-inflammatory responses in adrenaline-augmented myocardial injury in rats.

کلیدواژه ها:

Adrenaline ، Anti-oxidant ، Ascorbic acid ، Cardiac Biomarkers ، Gastric juice ، Myocardial injury