Studying the histopathological effects of aerobic training along with vitamin E consumption on heart tissue after methamphetamine consumption in adult male rats

Background and Objectives: Methamphetamine abuse causes tachycardia, tachypnea (hyperventilation), high blood pressure, rupture of heart vessels and increase of fibrotic tissue in the human heart. The aim of the present study is to investigate the histopathological effects of aerobic training and vitamin E consumption on the heart following the consumption of methamphetamine in male rats. methods: In this research, ۵۴ adult rats weighing ۲۵۰-۳۰۰ g were divided into ۶ groups: ۱. control group (healthy), ۲. addicted group (sham), ۳. addicted group + oral paraffin, ۴. addicted group + supplement ۵. addicted group + aerobic training, ۶- addicted + training+ supplement group. After ۲۳ days of methamphetamine injection, moderate intensity aerobic training was performed for ۶ weeks and ۱۵۰ mg/kg of vitamin E was administered by gavage. After this period, the rats were dissected and their hearts were removed. The data analyzed by one-way analysis of variance (ANOVA) and LSD post hoc test at a significance level of P ≤ ۰.۰۵. Results: The morphological investigation showed that there was a difference between the two groups of sham, paraffin with the control, supplement, training and supplement+training groups in the space between the endocardium, congestion and vascular rupture, and in the morphometric investigation, there was a difference in the hypertrophy of muscle fibers between the sham and paraffin groups with the control, supplement, training and supplement+training groups. Conclusion: It can be said that methamphetamine causes pathological hypertrophy of cardiomyocytes and destruction and rupture of blood vessels, and aerobic training along with vitamin E consumption causes physiological cardiac hypertrophy. Regarding the effect of vitamin E alone in the type of cardiac hypertrophy and vascular changes, more investigations are needed.

کلیدواژه ها:

Methamphetamine ، Aerobic training ، Vitamin E ، Hypertrophy