Niosomes containing mesoporous silica nanoparticles bound to zinc and containing tetracycline display antimicrobial and antibiofilm properties.

Antimicrobial resistance is a serious problem for human health and affects patients around the world. Antibiotics are powerful drugs that treat bacterial infections. Tetracyclines, discovered in the ۱۹۴۰s, are a family of antibiotics that inhibit protein synthesis by blocking the binding of aminoacyl-tRNA to the ribosomal receptor (A) site. Tetracyclines are broad-spectrum agents and show broad activity against gram-positive and gram-negative bacteria, abnormal organisms such as chlamydia, mycoplasma and rickettsia, and protozoan parasites. Zinc ions are among the substances that have traditionally been known and approved for their antimicrobial properties. Some studies have shown that ions of these metals inhibit proteins by binding to sulfhydryl (-SH) groups in enzymes. Zinc ions can also pass-through cell membranes and the increase of Inside Zn concentrations cause bacterial cell toxicity and death. MSN is widely used as delivery carriers because silica has favorable chemical properties, thermal stability, and biocompatibility. The unique structure of mesoporous silica facilitates the effective loading of drugs and their subsequent controlled release at the target site. On the other hand, nanoparticles are suitable carriers for the direct transfer and release of pharmaceutical agents such as antibiotics on infected surfaces and wounds. Niosomes are one of the new drug delivery systems that have received a lot of attention today due to their better penetration and controlled diffusion.

کلیدواژه ها:

Mesoporous silica nanoparticles (MSN) ، Tetracycline ، Zinc ، Niosome ، Antimicrobial ، Antibiofilm