Introduction and objective: Alzheimer's sickness (AD), is a neuropsychiatric ailment Identification of modifiable environmental hazard elements and Understanding the jobs of those heavy metals can appreciably effect prevention and remedy for AD and related dementias. proof shows that dysregulation withinside the homeostasis of vital metals and publicity to non-vital metals and heavy metals have great effect at the pathogenesis of (AD).Method: In the forthcoming systematic study, the required data were collected using keywords and citing valid databases such as: Scopus PubMed, Google Scholar and ProQuest. The statistical population of the study includes all studies conducted up to ۲۰۲۲ in the field of Alzheimer's Disease Association with Metals and Metalloids Concentration in
Blood and Urine. After reviewing the relevant Results and evaluating the data quality, a total of ۲۳ articles were analyzed.Result: In cell and animal version systems, lead, cadmium, or manganese remedy induces oxidative stress, neuroinflammation, and apoptosis in neurons. The degrees of barium (Ba), cobalt (Co), cesium (Cs), manganese (Mn), and thallium (Tl) in urine have been determined to be negatively related with the superiority of impaired cognitive basic performance in our cross-sectional investigation. Higher cadmium (Cd) degrees have been associated to cognitive impairment. The capability neurotoxicity of cadmium has been diagnosed due to the fact of excessive concentrations detected in mind tissues, liver, and plasma of Alzheimer’s sickness affected person in comparison to healthful individuals. excessive degrees of mercury had been detected withinside the blood of Alzheimer’s sufferers and modified into additionally determined in mind tissue, mercury withinside the anxious device has been proven to reason reminiscence loss, interest deficits and dementia a symptom of Alzheimer’s sickness. excessive degrees of aluminum had been determined in mind lesions, consisting of plaques and tangles, in sufferers with AD Cs, Mn, Ba, and Cd can be concerned in MCI pathogenesis, consisting of through manner of method of interfering with potassium channels or defensive neurons.Conclusion: AD and related dementias are currently incurable and constitute predominant public fitness challenges. physiological interest of vital metals. Because in their excessive diploma of toxicity, cadmium, lead and aluminum rank some of the precedence metals which are of public fitness significance. These metal factors are taken into consideration systemic toxicants.